Die u:cris Detailansicht:
Alike but Different
- Autor(en)
- Enrico Desideri, Anna Lina Cavallo, Manuela Baccarini
- Abstrakt
RAF links RAS, one of the most potent human oncogenes, to its effector ERK and to proliferation. This role is evolutionarily conserved, but while simpler multicellular organisms express one RAF, mammals have three. This Minireview highlights common and divergent features of RAF paralogs, their signaling outputs, and roles in tumorigenesis.
- Organisation(en)
- Department für Mikrobiologie, Immunbiologie und Genetik
- Journal
- Cell
- Band
- 161
- Seiten
- 967-970
- Anzahl der Seiten
- 4
- ISSN
- 0092-8674
- DOI
- https://doi.org/10.1016/j.cell.2015.04.045
- Publikationsdatum
- 05-2015
- Peer-reviewed
- Ja
- ÖFOS 2012
- 106022 Mikrobiologie
- Schlagwörter
- ASJC Scopus Sachgebiete
- Biochemistry, Genetics and Molecular Biology(all)
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/alike-but-different(f831bc36-784a-402d-9395-4e77277a310c).html