Neutralization of an Oxytocin Derivative by 355 nm Photocleavage in High Vacuum

Autor(en)

Yong Hua, Daniel Häussinger, Marcel Mayor, Valentin Köhler, Marcel Strauss, Martin F.X. Mauser, Tim Kostersitz, Philipp Geyer, Markus Arndt

Abstrakt

Controlling the charge state of biomolecules in high vacuum enables experiments in molecular physics and physical chemistry, particularly in applications of mass spectrometry, trapping and cooling, spectroscopy and matter-wave interferometry. Here we investigate the synthesis, verification and gas phase photolysis of nitrodibenzofuranmethyl aryl ether derivatives. These photocages are chosen because their absorption maximum can be tuned to near 355 nm, where intense pulsed laser light is available. We demonstrate efficient gas-phase cleavage of a photoactive nitrodibenzofuranmethyl aryl ether derivative, both free and attached to oxytocin. This enables the neutralization of a polypeptide derivative in high vacuum using a wavelength outside the absorption spectrum of natural amino acids.

Organisation(en)

Quantenoptik, Quantennanophysik und Quanteninformation

Externe Organisation(en)

Universität Basel

Journal

Helvetica Chimica Acta

Anzahl der Seiten

9

ISSN

0018-019X

DOI

https://doi.org/10.1002/hlca.202400167

Publikationsdatum

01-2025

Peer-reviewed

Ja

ÖFOS 2012

104017 Physikalische Chemie, 104026 Spektroskopie

Schlagwörter

ASJC Scopus Sachgebiete

Catalysis, Biochemistry, Drug Discovery, Physical and Theoretical Chemistry, Organic Chemistry, Inorganic Chemistry

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/f2773d15-a5ac-4c45-a707-955589deb11b