The impact of cross-linker distribution on magnetic nanogels: encapsulation, transport and controlled release of the tracer

Autor(en)

Ivan S. Novikau, Ekaterina V. Novak, Sofia S. Kantorovich

Abstrakt

Magnetic nanogels (MNGs) are highly attractive for biomedical applications because of their potential for remote control of the rheology and internal structure of these soft colloids with biocompatible magnetic fields. In this contribution, using molecular dynamics simulations, we investigate the impact of the cross-linker distribution in the body of a MNG on the shape and magnetic response to constant and AC magnetic fields and relate those properties to the behaviour of non-magnetic tracers placed in the MNGs and left to escape. We find that if no AC magnetic field is applied, although the escape times of the tracer particles barely depend on morphology, the highest degree of subdiffusion is observed for the gels with a non-uniform cross-linkerer distribution. We also find how the eigen frequency at which particles relax locally in the polymer matrix affects the dynamic magnetic response of the gel. We show that a magnetic field-induced wobbling can facilitate drug release from gels.

Organisation(en)

Computergestützte Physik und Physik der Weichen Materie

Externe Organisation(en)

Ural Federal University

Journal

Soft Matter

Band

20

Seiten

8765-8774

Anzahl der Seiten

10

ISSN

1744-683X

DOI

https://doi.org/10.1039/d4sm00797b

Publikationsdatum

10-2024

Peer-reviewed

Ja

ÖFOS 2012

103015 Kondensierte Materie

ASJC Scopus Sachgebiete

Allgemeine Chemie, Condensed Matter Physics

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/95cb1092-a64c-4c4e-83dd-6263e87e2ecd