Fundamental Bounds on the Precision of Classical Phase Microscopes

Autor(en)

Dorian Bouchet, Jonathan Dong, Dante Maestre, Thomas Juffmann

Abstrakt

A wide variety of imaging systems have been designed to measure phase variations, with applications from physics to biology and medicine. In this work, we theoretically compare the precision of phase estimations achievable with classical phase microscopy techniques, operated at the shot-noise limit. We show how the Cramér-Rao bound is calculated for any linear optical system, including phase-contrast microscopy, phase-shifting holography, spatial light interference microscopy, and local optimization of wavefronts for phase imaging. Through these examples, we demonstrate how this general framework can be applied for the design and optimization of classical phase microscopes. Our results show that wavefront shaping is required to design phase microscopes with optimal phase precision.

Organisation(en)

Quantenoptik, Quantennanophysik und Quanteninformation, Department für Strukturbiologie und Computational Biology

Externe Organisation(en)

Utrecht University, Université Paris IV - Paris-Sorbonne

Journal

Physical Review Applied

Band

15

Anzahl der Seiten

7

ISSN

2331-7019

DOI

https://doi.org/10.1103/PhysRevApplied.15.024047

Publikationsdatum

02-2021

Peer-reviewed

Ja

ÖFOS 2012

103021 Optik

ASJC Scopus Sachgebiete

Allgemeine Physik und Astronomie

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/9413025e-c003-4d8f-84ee-61a7d97efd38