Investigation of novel preclinical Total Body PET designed with J-PET technology: A simulation study

Autor(en)

M. Dadgar, S. Parzych, F. Tayefi Ardebili, J. Baran, N. Chug, C. Curceanu, E. Czerwinski, K. Dulski, K. Eliyan, A. Gajos, B. C. Hiesmayr, K. Kacprzak, L. Kaplon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemien, D. Kumar, S. Niedzwiecki, D. Panek, E. Perez del Rio, L. Raczynski, S. Sharma, Shivani, R. Y. Shopa, M. Skurzok, K. Tayefi Ardebili, S. Vandenberghe, W. Wislicki, E. L. Stepien, P. Moskal

Abstrakt

The growing interest in human-grade total body positron emission tomography (PET) systems has also application in small animal research. Due to the existing limitations in human-based studies involving drug development and novel treatment monitoring, animal-based research became a necessary step for testing and protocol preparation. In this simulation-based study two unconventional, cost-effective small animal total body PET scanners (for mouse and rat studies) have been investigated in order to inspect their feasibility for preclinical research. They were designed with the novel technology explored by the Jagiellonian-PET (J-PET) Collaboration. Two main PET characteristics: sensitivity and spatial resolution were mainly inspected to evaluate their performance. Moreover, the impact of the scintillator dimension and time-of-flight on the latter parameter was examined in order to design the most efficient tomographs. The presented results show that for mouse TB J-PET the achievable system sensitivity is equal to 2.35% and volumetric spatial resolution to 9.46 ± 0.54 mm

³, while for rat TB J-PET they are equal to 2.6% and 14.11 ± 0.80 mm

³, respectively. Furthermore, it was shown that the designed tomographs are almost parallax-free systems, hence, they resolve the problem of the acceptance criterion tradeoff between enhancing spatial resolution and reducing sensitivity.

Organisation(en)

Quantenoptik, Quantennanophysik und Quanteninformation

Externe Organisation(en)

Jagiellonian University in Krakow, National Centre for Nuclear Research (NCBJ), Ghent University , INFN - Laboratori Nazionali Di Frascati

Journal

IEEE Transactions on Radiation and Plasma Medical Sciences

Band

7

Seiten

124-131

Anzahl der Seiten

8

ISSN

2469-7311

DOI

https://doi.org/10.1109/TRPMS.2022.3211780

Publikationsdatum

10-2022

Peer-reviewed

Ja

ÖFOS 2012

302054 Nuklearmedizin

Schlagwörter

ASJC Scopus Sachgebiete

Instrumentation, Atomic and Molecular Physics, and Optics, Radiology Nuclear Medicine and imaging

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/8725e484-9075-421e-be2a-22f4f682a521