p38 links RAS to GATA2

Autor(en)

Christian Baumgartner, Manuela Baccarini

Abstrakt

More than 30% of all human cancers contain activating mutations of the small G-protein RAS. As a result of this, RAS has been intensely studied and many efforts have been made to identify pathways that sustain RAS-driven transformation. Recent studies have indicated that the transcription factor GATA2 is one of these partners in crime, but a mechanistic link between RAS and GATA2 had not been identified. A paper in this issue of EMBO reports closes this gap showing that GATA2 can be activated by p38 in RAS-transformed cells [3]..

Organisation(en)

Department für Mikrobiologie, Immunbiologie und Genetik

Journal

EMBO Reports

Band

15

Seiten

912-913

Anzahl der Seiten

2

ISSN

1469-221X

DOI

https://doi.org/10.15252/embr.201439309

Publikationsdatum

09-2014

Peer-reviewed

Ja

ÖFOS 2012

106013 Genetik

Schlagwörter

ASJC Scopus Sachgebiete

Genetics, Molecular Biology, Biochemistry

Sustainable Development Goals

SDG 16 – Frieden, Gerechtigkeit und starke Institutionen, SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/p38-links-ras-to-gata2(8112a8d1-6416-428b-a193-a90ebf0bc3dd).html