Dextran Nanoparticle Synthesis and Properties

Autor(en)

Iga Wasiak, Aleksandra Kullowska, Magdalena Janczewska, Magdalena Michalak, Iwona A. Cymerman, Andrzej Nagalski, Peter Kallinger, Wladyslaw Szymanski, Tomasz Ciach

Abstrakt

Abstract
Dextran is widely exploited in medical products and as a component of drug-delivering nanoparticles (NPs). Here, we tested whether dextran can serve as the main substrate of NPs and form a stable backbone. We tested dextrans with several molecular masses under several synthesis conditions to optimize NP stability. The analysis of the obtained nanoparticles showed that dextran NPs that were synthesized from 70 kDa dextran with a 5% degree of oxidation of the polysaccharide chain and 50% substitution with dodecylamine formed a NP backbone composed of modified dextran subunits, the mean diameter of
which in an aqueous environment was around 100 nm. Dextran NPs could be stored in a dry state and reassembled in water. Moreover, we found that different chemical moieties (e.g., drugs such as doxorubicin) can be attached to the dextran NPs via a pH-dependent bond that allows release of the drug with lowering pH.We conclude that dextran NPs are a promising nano drug carrier.

Organisation(en)

Aerosolphysik und Umweltphysik

Externe Organisation(en)

Warsaw University of Technology, NanoVelos Sp. z.o.o., Warsaw

Journal

PLoS ONE

Band

11

Anzahl der Seiten

17

ISSN

1932-6203

Publikationsdatum

01-2016

Peer-reviewed

Ja

ÖFOS 2012

104002 Analytische Chemie, 103039 Aerosolphysik, 210006 Nanotechnologie, 103008 Experimentalphysik

Schlagwörter

ASJC Scopus Sachgebiete

Allgemeine Agrar- und Biowissenschaften, General, Allgemeine Biochemie, Genetik und Molekularbiologie

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/68521de0-e893-49ec-b680-903e8a14269a