Highly sensitive single-molecule detection of macromolecule ion beams

Autor(en)

Marcel Strauß, Armin Shayeghi, Martin F.X. Mauser, Philipp Geyer, Tim Kostersitz, Julia Salapa, Olexandr Dobrovolskiy, Steven Daly, Jan Commandeur, Yong Hua, Valentin Köhler, Marcel Mayor, Jad Benserhir, Claudio Bruschini, Edoardo Charbon, Mario Castaneda, Monique Gevers, Ronan Gourgues, Nima Kalhor, Andreas Fognini, Markus Arndt

Abstrakt

The analysis of proteins in the gas phase benefits from detectors that exhibit high efficiency and precise spatial resolution. Although modern secondary electron multipliers already address numerous analytical requirements, additional methods are desired for macromolecules at energies lower than currently used in post-acceleration detection. Previous studies have proven the sensitivity of superconducting detectors to high-energy particles in time-of-flight mass spectrometry. Here, we demonstrate that superconducting nanowire detectors are exceptionally well suited for quadrupole mass spectrometry and exhibit an outstanding quantum yield at low-impact energies. At energies as low as 100 eV, the sensitivity of these detectors surpasses conventional ion detectors by three orders of magnitude, and they offer the possibility to discriminate molecules by their impact energy and charge. We demonstrate three developments with these compact and sensitive devices, the recording of 2D ion beam profiles, photochemistry experiments in the gas phase, and advanced cryogenic electronics to pave the way toward highly integrated detectors.

Organisation(en)

Quantenoptik, Quantennanophysik und Quanteninformation, Nanomagnetismus und Magnonik

Externe Organisation(en)

Universität Basel, Advanced Quantum Architecture Laboratory (AQUA), Single Quantum B.V., MS Vision, Österreichische Akademie der Wissenschaften (ÖAW)

Journal

Science Advances

Band

9

Anzahl der Seiten

9

ISSN

2375-2548

DOI

https://doi.org/10.1126/sciadv.adj2801

Publikationsdatum

12-2023

Peer-reviewed

Ja

ÖFOS 2012

103033 Supraleitung, 103042 Elektronenmikroskopie

ASJC Scopus Sachgebiete

General

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/66193ae1-d339-45b7-b308-1ea9227ee2ee