Structures and pathways for clathrin self-assembly in the bulk and on membranes

Autor(en)

Richard Matthews, Christos N. Likos

Abstrakt

We present a coarse-grained model of clathrin that is simple enough to be computationally tractable yet includes key observed qualitative features: a triskelion structure with excluded volume between legs; assembly of polymorphic cages in the bulk; formation of buds on a membrane. We investigate the assembly of our model using both Monte Carlo simulations and molecular dynamics with hydrodynamic interactions, in the latter employing a new membrane boundary condition. In the bulk, a range of known clathrin structures are assembled. A membrane budding pathway involving the coalescence of multiple small clusters is identified.

Organisation(en)

Computergestützte Physik und Physik der Weichen Materie

Journal

Soft Matter

Band

9

Seiten

5794-5806

Anzahl der Seiten

13

ISSN

1744-683X

DOI

https://doi.org/10.1039/c3sm50737h

Publikationsdatum

2013

Peer-reviewed

Ja

ÖFOS 2012

103036 Theoretische Physik, 102009 Computersimulation, 103029 Statistische Physik

Schlagwörter

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/4e1ab1e1-17a9-4736-82c9-ec86da949365